Investigação das correlações existentes entre o ciclo vigília-sono e a dor num modelo experimental de fibromialgia

Autores

  • Camila Naumann Pereira Universidade Regional de Blumenau
  • Beatriz Ferreira Nunes Universidade Regional de Blumenau
  • Edison Sanfelice André Universidade Regional de Blumenau https://orcid.org/0000-0002-6678-013X

DOI:

https://doi.org/10.5007/2175-7925.2020.e74455

Palavras-chave:

EEG, Fibromialgia, Modelo animal, Reserpina, Sono

Resumo

Os distúrbios do sono são altamente prevalentes em pacientes portadores de fibromialgia. Muitos dos sintomas diurnos, como sonolência excessiva diurna e fadiga, podem estar relacionados a padrões de sono não restaurador, que, associados aos quadros álgicos típicos da doença, se retroalimentam. Neste contexto, objetivamos estudar as possíveis correlações existentes entre o ciclo vigília-sono e os comportamentos álgicos em um modelo animal de fibromialgia induzido por injeções repetidas de reserpina. Foram utilizados ratos Wistar machos e fêmeas adultos que receberam implantes crônicos de eletrodos bipolares encefálicos e de EMG. Injeções de reserpina provocaram aumento na resposta à estimulação mecânica, detectada através do emprego do teste de von Frey. Nos ratos tratados com reserpina observou-se fragmentação do ciclo vigília-sono. Adicionalmente, observou-se a presença de comportamentos aberrantes acompanhados de modificações eletroencefalográficas notáveis quando comparados aos animais controle. Destaca-se, também, alterações em bandas de frequências específicas dos traçados de EEG correspondentes aos estados comportamentais de vigília atenta e de sono de ondas lentas. Por conta desses achados suspeita-se que o modelo de fibromialgia produzido por injeções de reserpina pode servir como modelo aplicável para esta doença em humanos.

Biografia do Autor

Camila Naumann Pereira, Universidade Regional de Blumenau

Acadêmica do curso de Medicina da Universidade Regional de Blumenau - Bolsista de iniciação científica pelo programa PIBIC-CNPq

Beatriz Ferreira Nunes, Universidade Regional de Blumenau

Acadêmica do curso de Medicina da Universidade Regional de Blumenau

Edison Sanfelice André, Universidade Regional de Blumenau

Professor titular do Departamento de Fisioterapia da Universidade Regional de Blumenau

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2020-12-09

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