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DOI:
https://doi.org/10.5007/%25xAbstract
The use of radiomodifying that alter the radiation effect, protecting or sensitizing cells and organisms, presents great interest in tumor radiotherapy. Glutathione (GSH) can be described as the major endogen radioprotector. The diethylmaleate (DEM) is a drug able to block intracellular GSH. This work aims at the establishment of the radiomodifyng competence of DEM administered in two different vehicles, peanut oil and aqueous ethanolic solution by the analysis of mouse survival curves as well as the relative percentagens of serum proteins. Groups of animals were previously injected intraperitoneally with 0.3 ml of 418 and 150 uM DEM respectively in each one of the vehicles one hour before irradiated with an 60Co acute dose of 9 Gy. The survival of mice was followed during 30 days and electrophoretic profiles of serum proteins 1,3 and 7 days after irradiation. The results showed that the action of DEM on muose radio sensivity depends on the vehicles used, considering that both media showed a radiomodifier action.Downloads
Published
1993-01-01
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