The Attacked Mouse: neurochemical, Physiological, and behavioral correlates

Authors

  • Bert Siegfried Institute of Pharmacology, University of Zurich, CH – 8006 Zurich, Switzerland.
  • Ricardo Luiz Nunes de Souza Laboratory of Psychobiology, FFCLRP, Campus of the University of São Paulo, 14049, Ribeirão Preto , Brazil.

DOI:

https://doi.org/10.5007/%25x

Abstract

The present work reviews  neurochemical, physiological and behavioral data recorded from the attacked mouse. The possible relationships between systems  of pain, memory and defense are presented, with special emphasis on the role of endogenous opioid peptides (EOPs). In recipients of attack, decreased  ? – endorphin- like immunoreativity  and changes in opiate and benzodiazepine binding characteristics  have been foud in structures of the brain defensive system. EOPs mediated the social conflict-induced increase  of dopamine systhesis in the  periaqueductal grey and frontal cortex. Social conflict analgesia in attacked mice was under the control of central  Opioid and nonopioid ( e.g ., benzodiazepine, glutamate) mechanisms, and was modified by experience ( e.g., long-term analgesic reaction; tolerance). EOPs and pain-inhibitory mechanisms participated in the organization of behavioral defense, recuperative behavior and the biologically-meaningful situation of murine social conflict allows investigation of defense, recuperative behavior and the memorization of attack experience. It is concluded that the biologically-meaningful situation of murine social conflict allows investigation of coping mechanisms at various levels and constitutes and alternative to existing animal models of aversion and defense.

Author Biographies

Bert Siegfried, Institute of Pharmacology, University of Zurich, CH – 8006 Zurich, Switzerland.

Institute of Pharmacology, University of Zurich,  CH – 8006 Zurich, Switzerland.

Ricardo Luiz Nunes de Souza, Laboratory of Psychobiology, FFCLRP, Campus of the University of São Paulo, 14049, Ribeirão Preto , Brazil.

Ricardo Luiz Nunes de Souza  Bolsista de Produtividade em Pesquisa 2 possui graduação em Enfermagem pela Universidade Federal de Santa Catarina (1984), mestrado (1988) e doutorado (1993) em Psicobiologia pela Universidade de São Paulo, especialização em Farmacologia pelo Instituto de Farmacologia da Universidade de Zurique e pós-doutorado pela Universidade de Leeds, Inglaterra (1999). Atualmente é professor adjunto (livre-docente) em Farmacologia da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP. Linha de Pesquisa: neurobiologia da dor e das reações de defesa. É editor associado da Revista de Ciências Farmacêuticas Básica e Aplicada e presta assessoria para Braz. J. Med. Biol. Res. - Behav. Brain Res. - Pharmacol. Biochem. Behav - Pharmacological Res. - Progress in Neuro-Psychopharmacol. Biol. Psychiatry - Neuroscience, Laboratory Animals, Psychopharmacology. Tem experiência na área de Farmacologia, com ênfase em Neuropsicofarmacologia, atuando principalmente nos seguintes temas: analgesia induzida pelo medo, comportamento defensivo, ansiedade, modelos animais de ansiedade. Certificado pelo autor em 15/12/11

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Published

1990-01-01

Issue

Vol. 3 No. 1 (1990)

Section

Artigos

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