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Authors

  • Eliete Motta Departamento de Biologia - UFSC)
  • Nadir Ferrari Departamento de Biologia - UFSC)

DOI:

https://doi.org/10.5007/%25x

Abstract

The aim of the present paper was to review the literature on hemophilia A, to diagnose hemophiliacs through FVIII:C and FVIII:RAg assays, to study their families and to detect heterozygotes for the condition. Twenty four persons were testes, from 6 families: 9 hemophiliacs A, 8 probable carriers and 7 definite carriers. Twenty five healthy women were also testes, with mean levels of FVIII:C and FVIII:RAg of 97+/-26% respectively. The mean levels of FVIII:C and FVIII:RAg for the definite carriers were 77+/-31% and 132+/-49% respectively. The methodology used in the present work for carrier detection is not ideal and DNA analysis should be introduced in brazilian genetic counselling services.

Author Biography

Nadir Ferrari, Departamento de Biologia - UFSC)

Possui Graduação em Farmácia e Bioquímica pela Universidade Estadual de Londrina, Mestrado em Genética pela Universidade Federal do Paraná e Doutorado em Genética Humana pela Oxford University.

Mais informações no Currículo Lattes.

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Published

1988-01-01

Issue

Vol. 1 No. 2 (1988)

Section

Artigos

License

After the electronic publication of the manuscript, the authors are entitled, without any restriction, on its contents.

License Creative Commons Atribuição 4.0 Internacional - CC BY

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Authors are able to take on additional contracts separately, non-exclusive distribution of the version of the paper published in this journal (ex.: publish in institutional repository or as a book), with an acknowledgment of its initial publication in this journal.