Lactate metabolism: bioenergetics and muscle fatigue review

Romulo Cássio de Moraes Bertuzzi, Adriano Lima-Silva, César Cavinato Cal Abad, Flávio de Oliviera Pires


The purpose of this study was to present the main events regarding the muscle lactate metabolism to aid the understanding about utilization of the blood lactate concentrations (BLC) on the estimative of lactic anaerobic metabolism and its likely relationship to the acute muscle fatigue. Traditionally, the increase of BLC was associated to the insufficient mitochondrial O2 supply. However, recent studies showed that increase of BLC can be due the action of another agent such as epinephrine and inorganic phosphate. In the same way, the relationship between BLC and acute muscle fatigue has been supported by increase in cellular acidosis. Nevertheless, recent studies have shown that cellular acidosis can restore the force in isolated and electrically stimulated muscle fibers. These findings suggest that utilization of the BLC on the estimative of lactic anaerobic metabolism should be used with caution and the relationship between BLC and acute muscle fatigue can only be a casual phenomenon.


Acidose celular; Ácido lático; Anaeróbio lático; Exercício;Cellular acidosis; Lactic acid; Anerobic lactic metabolism; Exercise


The abbreviated title of the journal is Rev. Bras. Cineantropom. Desempenho Hum, which should be used in bibliographies, footnotes and bibliographical references. E-ISSN 1980-0037, impressa ISSN 1415-8426, Florianópolis, Santa Catarina, Brazil. This work is licensed under a Creative Commons Attribution 4.0 International License.