A análise patentométrica como subsídio à gestão da inovação tecnológica: um estudo de caso em radiofármacos para câncer

Henrique Koch Chaves; Júlia Maria Brandão da Silva; Carla Cristina de Freitas da Silveira; Fabio Luiz Navarro Marques; Jorge Lima de Magalhães

doi:10.5007/1518-2924.2023.e92608

Authors

Henrique Koch Chaves Oswaldo Cruz Foundation https://orcid.org/0000-0003-3035-6799
Júlia Maria Brandão da Silva Oswaldo Cruz Foundation https://orcid.org/0000-0002-5284-7516
Carla Cristina de Freitas da Silveira Oswaldo Cruz Foundation https://orcid.org/0000-0001-7376-7948
Fabio Luiz Navarro Marques University of São Paulo https://orcid.org/0000-0001-7383-926X
Jorge Lima de Magalhães Oswaldo Cruz Foundation https://orcid.org/0000-0003-2219-5446

DOI:

https://doi.org/10.5007/1518-2924.2023.e92608

Keywords:

Patentometry, Information management, Public Health

Abstract

Objective: Prospect the evolution of patent applications onIdentify, extract, process data, organize and make available technological information in the form of graphical interfaces described in oncology patents containing the radioisotopes gallium-68 (⁶⁸Ga), copper-64 (⁶⁴Cu) and zirconium-89 (⁸⁹Z) in order to understand the development of science and technology in the area.

Method: The ORBIT Intelligence® platform from the company QUESTEL® was used to identify, extract, process the data, organize and make available the technological information in the form of graphical interfaces, analysis of the filed patents in force in the last 20 years in the main patent offices in the world.

Result: For gallium-68, copper-64 and zirconium-89, respectively, 36, 18 and 10 families of patents containing the search terms described in the methodology were identified. In both cases, China stands out in the number of filed patent applications, depositing 61% of the total analyzed. It was also observed that many of the analyzed documents were deposited by universities, reinforcing the concept of company-university partnership. The results obtained point out that the area of this study continues to grow and the understanding of the information present in the patent documents makes it possible to reflect on spaces to intensify the development of innovations in the oncology area.

Conclusions: The results obtained demonstrate the relevance of information for the management of a country's technological development, which can serve as an efficient method to analyze, compare and monitor research and development activities in cancer and also support the planning processes organizations, as well as supporting public and private health policies.

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Author Biographies

Henrique Koch Chaves, Oswaldo Cruz Foundation

I am currently a postdoctoral fellow at Fiocruz, working with Big Data in Public Health (2021). The investigations are carried out through the elaboration of prospective and technological scenarios with information science, Competitive Intelligence and Knowledge Management tools. Included in this context is the analysis of BIG DATA, Web 2.0, Health 2.0, Technological Trends, Marketing, Patents and Knowledge Translation. I have a master's degree and a PhD in Analytical and Inorganic Chemistry from the University of São Paulo (USP), having experience in the following subjects: 1) organometallic compounds, ruthenium complexes for homogeneous catalysis, polymers, olefin metathesis; 2) rhenium and technetium complex for pharmacological and medicinal applications, including applications as antitumor agents. Graduated in Chemistry from the Universidade Estadual de Santa Cruz (UESC).

Júlia Maria Brandão da Silva, Oswaldo Cruz Foundation

Bacharelanda em Farmácia no Centro Universitário Uniabeu (Belford Roxo - RJ) e faz iniciação científica na Fundação Oswaldo Cruz (Fiocruz), com bolsa da CNPq.

Carla Cristina de Freitas da Silveira, Oswaldo Cruz Foundation

PhD in Collective Health - Institute of Social Medicine (IMS) of the State University of Rio de Janeiro - UERJ (2016). Postgraduate in Management of Health Science and Technology Organizations - Fiocruz National School of Public Health (ENSP) (2014). Postgraduate in Civil Law and Civil Procedure - Universidade Gama Filho (2010). Bachelor of Laws - Estácio de Sá University (2008). Master in Science - Organic Chemistry - Federal University of Rio de Janeiro - UFRJ (1998). Bachelor in Chemistry with Technological Attributions (1992) and Degree in Chemistry (1991) - Faculty of Humanities Pedro II. She is currently a Health Management Analyst in Farmanguinhos, where she works as Coordinator of the Technological Innovation Center (NIT-FAR) of the Institute of Technology in Pharmaceuticals - FARMANGUINHOS/FIOCRUZ, Head Professor of the Lato Sensu Postgraduate Program in Pharmaceutical Industrial Technologies - TIF of Farmanguinhos/FIOCRUZ and Professor at the State Department of Education of Rio de Janeiro (SEEDUC), where he teaches Chemistry. She acted as: Intellectual Property Consultant at CENPES / PETROBRAS (2005-2009); Technical Consultant in the area of Industrial Property of Pharmaceutical Products and Processes in the Coordination of Intellectual Property (COOPI) of the National Health Surveillance Agency - ANVISA (2001-2005); Patent Analyst at the National Institute of Industrial Property - INPI (1998-2000); Member of the team responsible for structuring a Patent Database in the field of Fine Chemicals (Project: ALERT PATENTES) at the Brazilian Association of Fine Chemical Industries - ABIFINA (1993-1994). She has experience in the field of Chemistry and Medicines with an emphasis on Industrial Property. Judicial expert at the 9th and 17th VFRJ.

Fabio Luiz Navarro Marques, University of São Paulo

Bachelor of Science - Qualification in Chemistry from Faculdades Oswaldo Cruz (1991), Master's in Organic Chemistry from Instituto de Química - USP (1998) and Doctorate in Science from Faculdade de Medicina - USP (2007), in the area of experimental oncology. Professionally, I work as a chemist in the Radiopharmacy sector of the Nuclear Medicine Center of the Faculty of Medicine of the University of São Paulo (since 1994); as assistant director of the FMUSP board (since 2012); technical responsible for controlled chemical products at FMUSP (since 2011); member of the Waste Management Program Committee (since 2012). He works as a specific advisor in the postgraduate program in oncology at FMUSP. He is co-responsible for the postgraduate courses FBF5831-Fundamentals of Radiopharmacy: from Research to Applications (since 2019) and MCM5945-Radiopharmacy Practices and Molecular Imaging (since 2021). Supervisor/advisor of the radiopharmacy improvement/specialization program at Hospital das Clínicas - FMUSP (since 1999). He has experience in organic synthesis and radiopharmacy, working on the following topics: synthesis of molecules to obtain technetium [99mTc] complexes; radiopharmaceutical preparation of [99mTc]technetium, [18F]fluor, [89Zr]zirconium, [68Ga]gallium; biodistribution studies in cellular and animal models; development of analytical methodologies for quality control of radiopharmaceuticals and their precursors. It belongs to the research group Study in Molecular Imaging (http://dgp.cnpq.br/dgp/espelhogrupo/592827). Responsible for the Workshop Positron Emission Radiopharmaceuticals and Molecular Imaging (2014 and 2015) and Workshop Advances in Molecular Imaging and Radiopharmaceuticals (2018). Member of the Chemical-Pharmaceutical Technical Committee of the Regional Council of Chemistry IV Region (CRQ-IV since 2022).

Jorge Lima de Magalhães, Oswaldo Cruz Foundation

He holds a postdoctoral degree from Aix Marseille Université, France (Laboratoire IRSIC EA4262 - Institut de Recherche en Sciences de lInformation et de la Communication) in Competitive Intelligence for Public Health (2013). He holds a Doctor of Science degree from the Postgraduate Program in Chemical and Biochemical Process Technology at EQ / UFRJ-area of Management and Technological Innovation (2010) and a Master of Science from the same program (2007). He has a specialization in Business Administration and Management from Faculdades Simonsen (1998) and is an Industrial Chemist with a Full Degree from the Faculty of Philosophy Sciences and Letters Souza Marques (1996). He has more than 20 years of experience in Strategic Management in Pharmaceutical Industrial Operations. In the last 20 years, he has dedicated himself to R,D&I in the area of Public Health at FIOCRUZ, where he has published 5 books, 35 book chapters and several articles in national and international indexed journals. He works in Management and Technological Innovation at the Technological Innovation Center (NIT-Far) of the Farmanguinhos Institute of Technology in Pharmaceuticals / FIOCRUZ. In CNPq Research groups, he is the leader of the Knowledge Management and Health Prospecting group at FIOCRUZ, participates in the Chemical Industry Information System-SIQUIM at UFRJ and in the Technological Prospecting in Intellectual Property group at INPI. He is a guest researcher at the Global Health and Tropical Medicine (GHMT) of the Institute of Hygiene and Tropical Medicine (IHMT) at the NOVA University of Lisbon. Founding member of the International Platform for Science, Technology and Innovation in Health (PICTIS) and coordinator of the LabSec Pharmaceuticals, Medicines and Bioproducts of PICTIS at the University of Aveiro). The emphasis of his research permeates the identification, extraction and analysis of essential information within the "Big data" in Health regarding Management and Technological Innovation. The topics covered are inherent to Global Health, involving the pharmaceutical, pharmochemical and public health sectors. The investigations are carried out through the elaboration of prospective and technological scenarios with tools from information science, Competitive intelligence and Knowledge Management for Global Health and "One Health". This context includes the analysis of Big Data in health, business strategy in the pharmaceutical area, Digital Health, Technological Trends, Marketing, Patents and Knowledge Translation.

References

ALBERTS, D. et al. Introduction to Patent Searching. In: LUPU, M. et al. (Eds.). Current Challenges in Patent Information Retrieval. The Information Retrieval Series. Berlin, Heidelberg: Springer, 2011. p. 3–43.

ALBUQUERQUE, E. DA M. Empresas transnacionais e suas patentes no Brasil: resultados iniciais de uma investigação sobre a internalização de atividades tecnológicas. Revista de Economia Contemporânea, Rio de Janeiro, v. 4, n. 2, p. 85-111, 2000. Disponível em: https://revistas.ufrj.br/index.php/rec/article/view/19628. Acesso em: 06 set. 2023.

AL-LAZIKANI, B.; BANERJI, U.; WORKMAN, P. Combinatorial drug therapy for cancer in the post-genomic era. Nature Biotechnology, [S. l.], v. 30, n. 7, p. 679–692, 10 jul. 2012. Disponível em: https://europepmc.org/article/med/22781697. Acesso em: 06 set. 2023.

AMADEI, J. R. P.; TORKOMIAN, A. L. V. As patentes nas universidades: análise dos depósitos das universidades públicas paulistas (1995-2006). Ciência da Informação, Brasília, v. 38, n.2, p. 9-18, ago. 2009. Disponível em: https://www.scielo.br/j/ci/a/MYdP3fsztxHs89XzWFkgdmj/. Acesso em: 06 set. 2023.

BINNS, R.; DRISCOLL, B. Intellectual property issues in R&D contracts. Pharmaceutical Science & Technology Today, [S.l.], v. 1, n. 3, p. 95–99, 1 jun. 1998. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S1461534798000339. Acesso em: 06 set. 2023.

BLASI, C. G. D. A propriedade industrial: os sistemas de marcas, patentes e desenhos industriais analisados a partir da Lei n. 9.279, de 14 de maio de 1996. Forense: Rio de Janeiro, 2005.

BLINNIKOV, V. I.; BELOV, V. V.; MAKAROV, M. A. Some problems in the use of the international patent classification. World Patent Information, [S. l.], v. 6, n. 2, p. 63–68, 1 jan. 1984. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/0172219084900711. Acesso em: 06 set. 2023.

CARPENTER, A. M.; JONES, M.; OPPENHEIM, C. Consistency of use of the International Patent Classification. Knowledge Organization, [S. l.], v. 5, n. 1, p. 30-32, 1978. Disponível em: https://www.nomos-elibrary.de/10.5771/0943-7444-1978-1-30.pdf. Acesso em: 06 set. 2023.

CHEN, Y. et al. Report on the development and application of PET/CT in mainland China. Oncotarget, [S. l.], v. 8, n. 38, p. 64417–64426, 16 mar. 2017. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610013/. Acesso em: 06 set. 2023.

CONSELHO NACIONAL DE SAÚDE (Brasil) (CNEN). RMB e a Produção de Radiofármacos. Brasília, c2015. Disponível em: http://antigo.cnen.gov.br/radiofarmacos. Acesso em: 5 maio. 2022.

CONSELHO NACIONAL DE SAÚDE (Brasil) (CNEN). CNS recomenda ao governo investimento de R$ 89,7 milhões para que SUS continue produção de radiofármacos até o final do ano. Brasília, 2021. Disponível em: http://conselho.saude.gov.br/ultimas-noticias-cns/2223-cns-recomenda-ao-governo-investimento-de-r-89-7-milhoes-para-que-sus-continue-producao-de-radiofarmacos-ate-o-final-do-ano. Acesso em: 5 maio. 2022.

D’HONDT, E. et al. Dealing with temporal variation in patent categorization. Information Retrieval, [S. l.], v. 17, n. 5, p. 520–544, 1 out. 2014. Disponível em: https://link.springer.com/article/10.1007/s10791-014-9239-6. Acesso em: 06 set. 2023.

GERMERAAD, P.; VANHAVERBEKE, W. Seize your open innovation opportunities by leveraging ip databases. CIMS Innovation Management Report, p. 7–12, 1 mar. 2017.

GLOBAL CANCER OBSERVATORY. Cancer today. France: WHO, 2020. Disponível em: http://gco.iarc.fr/today/home. Acesso em: 14 jul. 2023.

GRABOWSKI, H. Patents, Innovation and Access to New Pharmaceuticals. Journal of International Economic Law, [S. l.], v. 5, n. 4, p. 849–860, 1 dez. 2002. Disponível em: https://academic.oup.com/jiel/article-abstract/5/4/849/948415. Acesso em: 06 set. 2023.

GUERREIRO, E. S. et al. Análise de documentos de patentes sobre copaiba: uma comparação entre fontes de dados. Cadernos de Prospecção, Salvador, v. 11, n. 1, p. 26–26, 1 abr. 2018. Disponível em: https://periodicos.ufba.br/index.php/nit/article/view/22725. Acesso em: 06 set. 2023.

HANNEY, S. R. et al. How long does biomedical research take? Studying the time taken between biomedical and health research and its translation into products, policy, and practice. Health Research Policy and Systems, [S. l.], v. 13, p. 1, 1 jan. 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25552353/. Acesso em: 06 set. 2023.

HOLOHAN, C. et al. Cancer drug resistance: an evolving paradigm. Nature Reviews. Cancer, [S. l.], v. 13, n. 10, p. 714–726, out. 2013. Disponível em: https://pubmed.ncbi.nlm.nih.gov/24060863/. Acesso em: 06 set. 2023.

IHEALTHCAREANALYST, I. Global Radiopharmaceuticals Market $537 Million by 2029. Missouri, 2023. Disponível em: https://www.ihealthcareanalyst.com/global-radiopharmaceuticals-market/. Acesso em: 06 set. 2023.

INSTITUTO NACIONAL DE CÂNCER (Brasil) (INCA). Estimativa. Brasília, 2023. Disponível em: https://www.inca.gov.br/estimativa. Acesso em: 06 set. 2023.

INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL (INPI). Bases de patentes online. Brasília, 2015. Disponível em: https://www.gov.br/inpi/pt-br/assuntos/informacao/bases-de-patentes-online. Acesso em: 14 jul. 2023.

INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL (INPI). Patentes. Brasília, 2020. Disponível em: https://www.gov.br/inpi/pt-br/servicos/perguntas-frequentes/patentes. Acesso em: 14 jul. 2023.

INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL (INPI) Classificação de patentes — Português (Brasil). Brasília, 2023. Disponível em: https://www.gov.br/inpi/pt-br/servicos/patentes/classificacao-de-patentes. Acesso em: 06 set. 2023.

KOWALSKY, R. J.; WEATHERMAN, K. D. Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine,. Washington: American Pharmacists Association, 2004.

MAGALHÃES, J. L. DE et al. Big Data e a saúde negligenciada em dengue, zika e chicungunha: uma análise translacional da tríplice ameaça no século 21. Ciência da Informação, Rio de Janeiro, v. 13, n. 1, 7 maio 2018. Disponível em: https://revista.ibict.br/ciinf/article/view/4061. Acesso em: 06 set. 2023.

MEGURO, K.; OSABE, Y. Lost in Patent Classification. World Patent Information, [S. l.], v. 57, p. 70–76, 1 jun. 2019. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0172219018301340?dgcid=rss_sd_all. Acesso em: 06 set. 2023.

MORDOR INTELLIGENCE. China Relatório de mercado de imagens nucleares | Tamanho, participação, crescimento e tendências (2023-28). Telangana, 2022. Disponível em: https://www.mordorintelligence.com/industry-reports/china-nuclear-imaging-market. Acesso em: 14 jul. 2023.

NANAYAKKARA, D. Report on the Current Nuclear Medicine Status of the Asian Member States from the Initial Cooperative Project Meeting (RAS6061/9001/01) of International Atomic Energy Agency/Regional Cooperative Agreement (IAEA/RCA). Austral-Asian Journal of Cancer, [S. l.], v. 12, p. 135–145, 1 jul. 2013.

OLIVEIRA, R. et al. Preparações radiofarmacêuticas e suas aplicações. Revista Brasileira de Ciências Farmacêuticas, São Paulo, v. 42, p. 151–165, jun. 2006. Disponível em: https://www.scielo.br/j/rbcf/a/RjFqKQxWrfCHv8Z4hqgq68m/. Acesso em: 06 set. 2023.

PERINI, E. A. et al. Pre-feasibility Study for establishing radioisotope and radiopharmaceutical production facilities in developing countries. Current Radiopharmaceuticals, [S. l.], v. 12, n. 3, p. 187–200, 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30924426/. Acesso em: 06 set. 2023.

SAHA, G. Fundamentals of Nuclear Pharmacy. 7. ed. [S. l.]: Springer International Publishing, 2018.

SPEZIALI, M. G.; GUIMARÃES, P. P. G.; SINISTERRA, R. D. Desmistificando a proteção por patentes nas universidades. Química Nova, São Paulo, v. 35, n. 8, p. 1700–1705, 2012. Disponível em: https://www.scielo.br/j/qn/a/5WvPGQtZPTFYbQCCJytyPyq/. Acesso em: 06 set. 2023.

SPEZIALI, M. G.; NASCIMENTO, R. DA S. Patentometria: uma ferramenta indispensável no estudo de desenvolvimento de tecnologias para a indústria química. Quimica Nova, São Paulo, v. 43, n. 10, p. 1538–1548, 2020. Disponível em: https://quimicanova.sbq.org.br/detalhe_artigo.asp?id=9173. Acesso em: 06 set. 2023

TOLEDO, P. T. M. DE; LOTUFO, R. DE A. A relevância da proteção e da transferência dos resultados de pesquisas acadêmicas. Journal of the Brazilian Chemical Society, São Paulo, v. 22, p. 1005–1006, jun. 2011. Disponível em: https://www.scielo.br/j/jbchs/a/FzmBKtWFtRD7yZrcsj8VKpz/?lang=pt. Acesso em: 06 set. 2023

WANG, B.; CHAI, K.-H.; SUBRAMANIAN, A. M. Roots and development of intellectual property management research: A bibliometric review. World Patent Information, [S. l.], v. 40, p. 10–20, 1 mar. 2015. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0172219014001586. Acesso em: 06 set. 2023

WORLD HEALTH ORGANIZATION (WHO). Câncer de mama agora forma mais comum de câncer: OMS tomando medidas. [S. l.], 2021. Disponível em: https://www.who.int/pt/news/item/03-02-2021-breast-cancer-now-most-common-form-of-cancer-who-taking-action. Acesso em: 4 maio. 2022.

ZAPAROLLI, D. Radiofármacos sob ameaça. Pesquisa FAPESP, ed. 309, p. 66-69, nov. 2021. Disponível em: https://revistapesquisa.fapesp.br/radiofarmacos-sob-ameaca/. Acesso em: 6 maio. 2022.