Bone mineral density in independent elderly women with different physical and functional profiles and vitamin D receptor gene polymorphisms

Myriam Fernanda Merli, Regina Célia Poli Fredico, Emily Delalibera Ruzzon, Rubens Alexandre da Silva Junior, Karen de Barros Parron Fernandes, Denilson de Castro Teixeira, Audrey de Souza Marquez, Vanessa Suziane Probst


The aim of the study was to compare BMD among physically independent elderly women with different physical-functional profiles and vitamin D receptor gene (VDR) polymorphisms, as well as to analyze the effect of the interaction between these last two aspects on BMD. Overall, 165 elderly women had BMD assessed by bone densitometry. Handgrip and lower limb strength and functional exercise capacity (6MWT) were also assessed. VDR polymorphisms (TaqI, BsmI, ApaI and FokI) were analyzed by polymerase chain reaction. For analyses, elderly women were categorized according to their performance on physical-functional tests into low performance (LP; <25th percentile), normal performance (NP; 25th percentile ≤ NP ≤ 75thpercentile) and high performance (HP;> 75th percentile). Regarding functional exercise capacity, LP group showed lower BMD compared to HP and NP groups (p=0,003). With respect to handgrip strength, there was a trend for LP group to have lower bone mineral density compared to NP group (p=0.08). No differences were observed in femur and lumbar BMD in comparisons among the different VDR genotypes (0.07≤p≤0.94); among different groups regarding lower limb strength (p=0.49) and in the interaction analysis among variables (0.17≤p≤0.77). It was concluded that physically independent elderly women with low functional exercise capacity have lower bone mineral density than those classified as normal and high performance. However, apparently, there is no effect of the interaction between VDR gene polymorphisms and physical and functional factors on BMD.


Elderly; Bone density; Exercise tolerance; Genetics

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The abbreviated title of the journal is Rev. Bras. Cineantropom. Desempenho Hum, which should be used in bibliographies, footnotes and bibliographical references. E-ISSN 1980-0037, impressa ISSN 1415-8426, Florianópolis, Santa Catarina, Brazil. This work is licensed under a Creative Commons Attribution 4.0 International License.