Densidade mineral óssea de idosas independentes com diferentes perfis físico-funcionais e polimorfismos do gene do receptor da vitamina D

Myriam Fernanda Merli; Regina Célia Poli Fredico; Emily Delalibera Ruzzon; Rubens Alexandre da Silva Junior; Karen de Barros Parron Fernandes; Denilson de Castro Teixeira; Audrey de Souza Marquez; Vanessa Suziane Probst

doi:10.1590/1980-0037.2016v18n1p20

Authors

Myriam Fernanda Merli University of Northern Parana
Regina Célia Poli Fredico University of Northern Parana
Emily Delalibera Ruzzon University of Northern Parana
Rubens Alexandre da Silva Junior University of Northern Parana
Karen de Barros Parron Fernandes University of Northern Parana
Denilson de Castro Teixeira University of Northern Parana
Audrey de Souza Marquez University of Northern Parana
Vanessa Suziane Probst State University of Londrina

DOI:

https://doi.org/10.1590/1980-0037.2016v18n1p20

Abstract

The aim of the study was to compare BMD among physically independent elderly women with different physical-functional profiles and vitamin D receptor gene (VDR) polymorphisms, as well as to analyze the effect of the interaction between these last two aspects on BMD. Overall, 165 elderly women had BMD assessed by bone densitometry. Handgrip and lower limb strength and functional exercise capacity (6MWT) were also assessed. VDR polymorphisms (TaqI, BsmI, ApaI and FokI) were analyzed by polymerase chain reaction. For analyses, elderly women were categorized according to their performance on physical-functional tests into low performance (LP; <25th percentile), normal performance (NP; 25th percentile ? NP ? 75thpercentile) and high performance (HP;> 75th percentile). Regarding functional exercise capacity, LP group showed lower BMD compared to HP and NP groups (p=0,003). With respect to handgrip strength, there was a trend for LP group to have lower bone mineral density compared to NP group (p=0.08). No differences were observed in femur and lumbar BMD in comparisons among the different VDR genotypes (0.07?p?0.94); among different groups regarding lower limb strength (p=0.49) and in the interaction analysis among variables (0.17?p?0.77). It was concluded that physically independent elderly women with low functional exercise capacity have lower bone mineral density than those classified as normal and high performance. However, apparently, there is no effect of the interaction between VDR gene polymorphisms and physical and functional factors on BMD.